In this zombie thriller set in Korea's medieval Joseon dynasty which has been defeated by corruption and famine, a mysterious rumor of the king’s death spreads, as does a strange plague that renders the infected immune to death and hungry for flesh. The crown prince, fallen victim to a conspiracy, sets out on a journey to unveil the evil scheme and save his people.
As the Joseon King succumbs to smallpox the rumors of his death begin. The Cho Clan, which is the clan of the pregnant Queen and her father, together with the the Chief State Councillor, Cho Hak Joo, declare the Crown Prince a traitor.
Questioning the circumstances surrounding the King’s death, the Crown Prince and his guard, Moo Young, set out to locate Lee Seung Hui, the last physician to treat his father. But the two end up stuck with Assistant Physician Seo Bi and a mysterious man named Young Shin in a village plagued with a terrifying disease.